MB ARDESHIR LARIJANI; SM TAVANGAR; AR SHAFAHI; A LASHKARI; M RASOULINEZHAD; R HESHMAT; M IZADI; V HAGHPANAH; SH AFHAMI; M MOHRAZ
Volume 13, Issue 4 , January and February 2007, , Pages 166-171
Abstract
Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism ...
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Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism in HIV-infected patients.
Methods and Materials: Free T4, FT3, TSH, and thyroglobulin levels of 88 HIV-infected patients receiving care at UT counseling center for Behavioral Disorders in Tehran, an out patient referral center, were measured and data on their age, sex, body weight, BMI, history of opium and injection addictions, duration of HIV infection, disease stage, history of opportunistic infection or malignancy, CD4 cell count, antiretroviral treatment with antiretroviral drugs (HAART), receipt of other drugs (TMP-SMX, antituberculosis drugs, and steroids), and hepatitis C virus Co-infection were collected. Inclusion of the subjects was simply random.
Results:17% of subjects had hypothyroidism; 1.1% had overt hypothyroidism; 2.3% subclinical hypothyroidism and 13.6% had low FT4 levels. The multivariate analysis showed that none of the studied factors were associated with the development of hypothyroidism.
Conclusion: As none of the above-mentioned factors are not associated with the development of hypothyroidism, hypothyroidism should be considered in HIV-infected patients.
MB ARDESHIR LARIJANI; R MALEKZADEH; V HAGHPANAH; B SOLEYMANPOUR; R HESHMAT; SM TAVANGAR
Volume 13, Issue 4 , January and February 2007, , Pages 190-195
Abstract
Background and Purpose: This study was intended to record the number of endocrine cancer in four provinces of Iran.
Methods and Materials: Patients in each province were classified according to their age, gender, sex, and tumor characteristics (site, morphology and behavior). The obtained data were ...
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Background and Purpose: This study was intended to record the number of endocrine cancer in four provinces of Iran.
Methods and Materials: Patients in each province were classified according to their age, gender, sex, and tumor characteristics (site, morphology and behavior). The obtained data were coded according to ICD-O. High- risk age was calculated for each province and the results presented as incidence rates by sex, age, age- specific rates and ASR per 100,000 person – years using standard statistical methods to the world population.
Results: Out of 319 cases of primary endocrine cancers found and recorded, 313 cases were thyroid carcinoma and 6 cases were adrensal cancers. In thyroid carcinoma group, the share of Papillary, follicular, medullary and anaplastic carcinomas accounted for 82.7%, 8.6%, 7.0% and 1.6% respectively. Also, the ASR of thyroid carcinoma for total, male and female cases were 1.289, 0.627 and 1.59 respectively. The highest incidence rate of the thyroid carcinoma was found in Kerman with the ASR of 1.643 for both genders and the lowest rate in Golestan with the ASR of 0.735. Mean age of patients was 43.9 years (SD=15.90) and their age ranged from 3 to 8 years. This figure for males was 45.21 (± 17.13) and for females 43.49 (±15.51) (P= 0.41). Also, the female - male ratio was 3.1 to 1. In adrenal cases (n=6), 4 cases (66.7%) had neuroblastoma and 2 cases were pheochromocytoma (33.3%). The mean diagnosis age was 16.17 (± 7.05) years for the whole population of cases; 13.00 (±3.46) years for males and 19.33 (±9.07) for females (P=0.32)
Conclusion: Iran was considered as an endemic iodine-deficient region until fairly recently. However, iodinization of salt started 12 years ago and since then, this increase has caused an increase in the incidence of papillary cancer, compared to other thyroid carcinomas; its frequency and distribution closely correspond to the observed profile in areas with high iodine consumption.
N SEDDIGHI; MB ARDESHIR LARIJANI; S SHARGHI; R HESHMAT; P SHOUSHTARIZADEH; V HAGHPANAH; B RAJABI POUR; A LASHKARI
Volume 13, Issue 3 , September and October 2006, , Pages 116-121
Abstract
Background and Purpose: Serum soluble Fas (sFas) is found in low concentrations in the sera of healthy subjects and it elevated in patients with autoimmune diseases, malignancy and inflammatory diseases. The Fas molecules play some role in the pathogenesis of Graves’ disease through interfering with ...
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Background and Purpose: Serum soluble Fas (sFas) is found in low concentrations in the sera of healthy subjects and it elevated in patients with autoimmune diseases, malignancy and inflammatory diseases. The Fas molecules play some role in the pathogenesis of Graves’ disease through interfering with the Fas-FasL interaction. Therefore, this study was conducted to evaluate the relationship between soluble Fas serum level and thyroid autoantibodies.
Methods and Materials: In order to determine the association of serum sFas level with thyroid autoantibodies, we evaluated the serum levels of sFas and thyroid antibodies in 31 untreated GD patients and 37 respective healthy controls.
Results: sFas serum level was reported to be higher in patients than in healthy subjects (P
SM TAVANGAR; MB ARDESHIR LARIJANI; A MAHTA; V HAGHPANAH; A LASHKARI; R HESHMAT
Volume 13, Issue 2 , July and August 2006, , Pages 99-104
Abstract
Background and Purpose: Pituitary adenomas without clinically active hypertension are termed as non-functioning adenoma (NFPA). These tumors represent about one quarter of all pituitary tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen ...
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Background and Purpose: Pituitary adenomas without clinically active hypertension are termed as non-functioning adenoma (NFPA). These tumors represent about one quarter of all pituitary tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1, whose labeling index (LI) is considered as a marker of normal and abnormal cell proliferation.
Methods and Materials: In this clinicopathological study, 85 cases of NFPAs were analyzed immunohistochemically.
Results: MIB-1 LI was measured in all surgical specimens, which was higher than 5% only in 5 cases. Also, 18 cases were immunoactive to one or two adenohypophysial hormones.
Conclusion: NFPAs comprise several pathologically different types of tumors, some of which are potentially hormone producing tumors. However, probable defects in hormone secretion may be the cause of not increasing the adenohypophysial hormone levels in the serum and consequent syndromes.
MB ARDESHIR LARIJANI; M MOTASADDI; H HADIZADEH; A FARD ESFAHANIAN; R HESHMAT; O TABATABAEI; S SHARGHI; V HAGHPANAH; E TAHERI; A LASHKARI
Volume 13, Issue 1 , March and April 2006, , Pages 33-39
Abstract
Background and purpose: Pendred syndrome, defined traditionally as the constellation of goiter, sensori-neural hearing loss and positive perchlorate discharge test. Since the relatively newer approaches to the diagnosis of this syndrome, as MRI and genetic and/or molecular analysis are much more expensive ...
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Background and purpose: Pendred syndrome, defined traditionally as the constellation of goiter, sensori-neural hearing loss and positive perchlorate discharge test. Since the relatively newer approaches to the diagnosis of this syndrome, as MRI and genetic and/or molecular analysis are much more expensive and complicated than the traditional approaches, we planned to study the value and reliability of MRI as the sole, or adjunctive diagnostic approach to the syndrome. Materials and methods: We presumed the classic triad is still the most widely accepted gold standard, and compared MRI findings in six such defined patients with six seemingly incomplete forms with goiter and hearing loss, but with negative Perchlorate discharge test.
Results: There were a sensitivity and specificity of 83.3% and 66.7%, respectively for MRI in patients fulfilling all three criteria and 66.7% and 100% for sensitivity and specificity in the group lacking perchlorate test positivity. Conclusion: Although MRI can not replace the holistic approach, In "partial" cases with equivocal findings, and in the evaluation of relatives of the patients MRI may be considered as a valuable diagnostic adjunct.
H PAK; F ALBORZI; A LASHKARI; SH BARZEGAR; SH GHAFARI; M SAEIDI; V HAGHPANAH; P RAHIMPOUR; P SHOUSHTARIZADEH; R HESHMAT
Volume 13, Issue 1 , March and April 2006, , Pages 40-45
Abstract
Background and purpose: Vitamin D is an antiproliferative agent against cancer cells and regulates cell differentiation. It acts via Vitamin D Receptor (VDR). The VDR gene contains a Start Colon Polymorphism (SCP) that can be detected with the restriction enzyme Fok I. Previous studies report an association ...
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Background and purpose: Vitamin D is an antiproliferative agent against cancer cells and regulates cell differentiation. It acts via Vitamin D Receptor (VDR). The VDR gene contains a Start Colon Polymorphism (SCP) that can be detected with the restriction enzyme Fok I. Previous studies report an association of SCP and some diseases and some suggest that this polymorphism alters VDR function. As no studies so far have reported the association between Fok I genotype in Thyroid cancer, this study is intended to determine the association of Fok I polymorphism of VDR with thyroid cancer risks in Iranian population.
Methods and Materials: 58 patients with papillary carcinoma, 13 patients with follicular carcinoma and 82 controls participated in a case-control study. A PCR-RFLP method used to determine VDR gene polymorphism in start codon characterized by the restriction enzyme Fok I. 95% confidence intervals and odds ratio were calculated for testing the relationship between Fok I polymorphism and thyroid cancer.
Results: The odds ratio for the Fok I polymorphism on thyroid cancer was 0.39 (95% CI, 0.12-1.27), witch signifies no relationship between this polymorphism and the ris of thyroid cancer.
Conclusion: As no relationship was found between this polymorphism and thyroid cancer, other genetic or environmental factors may be considered in thyroid cancer.